SOLUTIONS FOR LIFE

Nikovari Bio Tech Oy is a biotechnology company established in Helsinki, Finland in 2017, backed with a combined experience and track record of 20 years in orthopaedics of the founding team. We are committed to delivering meaningful solutions in early intervention orthopedic care including osteoarthritis pain management and other joint preservation options to people suffering from degenerative joint pathology to relieve their pain and improve their quality of life.

INTRA-ARTICULAR INJECTIONS FOR A LONG TERM TREATMENT OF SYMPTOMATIC OSTEOARTHRITIS

PAIN RELIEF, RESTORED MOBILITY AND JOINT RECOVERY TO MEET ALL YOUR CLINICAL NEEDS

BIOPORT® PLUS 1,5%

30 mg hyaluronic acid per syringe
Three injections per treatment

BIOPORT® CROSSLINK 2%

60 mg hyaluronic acid | 90 mg chondroitin sodium sulfate per syringe
Only one injection per treatment

BIOPORT® LINEAR 80

80 mg hyaluronic acid per syringe (20mg / ml) 4 ml pre-flled syringe
Only one injection per treatment

BIOPORT® TRICOMBO

36 mg hyaluronic acid | 67,5 mg chondroitin sodium sulfate per syringe
Only one injection per treatment

HYALURONIC ACID – A MULTITASKING MOLECULE

Provides anti-inflammatory, anabolic and chondroprotective actions, contributing to increase in viscosity and restored properties of synovial fluid.

BIOPORT® LINEAR 80

Is a sterile, biodegradable, isotonic, injectable gel, for intra-artcular use. BIOPORT® LINEAR 80 consists of medium chain (1.0-1.5 x 106 Dalton) hyaluronic acid, obtained from Streptococcus equi bacteria, formulated to a concentraton of 20 mg/ml in a physiologic bufer. The product, improving the characteristcs of the synovial fuid, exerts a protectve acton of the joints and helps the improvement of joint functon and the reducton of pain symptoms.

  • Composition: Sodium hyaluronate

  • Concentration: 80 mg/4ml 2%

  • Administration total: 1 syringe at 6 months

  • Average molecular weight: 1.5 MDa

  • Viscosity (cP): 150.000-290.000

  • Osmolality (mOsm/kg): 270-330

  • 80 MG HYALURONIC ACID PER SYRINGE (20 MG / ML) 4 ML PRE-FILLED SYRINGE

BIOPORT® LINEAR 80 /// PROPERTIES

Only one injection per treatment

Highly concentrated: 80 mg of linear hyaluronic acid per syringe

Delivered in pre-filled glass syringe Becton Dickinson

HYALURONIC ACID

Hyaluronic acid with a constant molecular weight between 1,200 and 1,500 kD allows optmal diffusion within the cartilage cell, reducing the risk of painful swelling of the injection site. Produced by Biofermentation of Streptococcus equi with no animal protein, it results in absolute purity, reducing the risk of allergens and inflammatory reactions to a minimum. Native hyaluronic acid (not chemically modified)

INDICATION

BIOPORT® LINEAR 80 is a synovial fuid substitute which, thanks to its viscoelastic and lubricant properties, promotes the restoration of rheological conditions of the joints, altered in degenerative or post-traumatic conditions. The product, improving the characteristics of the synovial fuid, exerts a protective action of the joints and helps the improvement of joint function and the reduction of pain symptoms.

EFFECTS

  • Reduces pain
  • Improves joint function and joint stiffness
  • May postpone joint replacement

APPLICATION

A single injecton of the product restores the protection of the joint through good lubrication and shock absorption and leads to a significant improvement in symptoms.

OSTEOARTICULAR PATHOLOGIES AFFECT ABOUT 10% OF THE GLOBAL POPULATION.

Among these, osteoarthritis is one of the most frequent disorders, which is estimated to affect at least 57 million people in Europe alone.

BIOPORT® PLUS 1,5%

It replaces or reinforces the synovial fluid in the joints and is recommended for symptomatic treatment of synovial joint degeneration, including bone and joint inflammation.

  • Composition: Sodium hyaluronate
  • Concentration: 30 mg/2ml 1.5%
  • Administration total: 3 syringes, 1 week apart from each other

  • Average molecular weight: 1.8-2.6 MDa
  • 30 MG HYALURONIC ACID PER SYRINGE (15 MG / ML) 2 ML PRE-FILLED SYRINGE

BIOPORT® PLUS 1,5% /// PROPERTIES

Three injections per treatment

Highly purified 30mg hyaluronic acid per syringe

Highest degree of compatibility with properties of synovial fluid

Free from animal proteins

Delivered in pre-filled glass syringe Becton Dickinson

SODIUM HYALURONATE

In medical devices containing sodium hyaluronate for the viscoelastic supplementation of the synovial fluid, it is very important for the gel to imitate to the highest extent the synovial fluid and to be as close as possible to its properties, degrading as hard as possible in the joint.

INDICATION

  • As a viscoelastic supplement or a replacement for synovial fluid in human knee joints
  • For symptomatic treatment of knee osteoarthritis

EFFECTS

  • Lubricant and mechanical support
  • Improvement of joint mobility

APPLICATION

Depending on the degree of discomfort, about one injection per week, about 3 injections per treatment course. The effect can be sustained over a period of about 6 months.

BIOPORT PROVIDES PAIN RELIEF, LUBRICATION AND MECHANICAL SUPPORT.

BIOPORT is a sterile, viscoelastic solution for intra-articular injection.

BIOPORT® CROSSLINK 2%

It is a sterile viscoelastic solution for intra-articular injection, the two cross-linked biological polymers, sodium hyaluronate and chondroitin sodium sulfate involves.

  • Composition: Sodium hyaluronate, Chondroitin sodium sulfate

  • Concentration: 60 mg/90 mg/3ml 2%/3%

  • Administration total: 1 syringe at 6 months

  • Average molecular weight: 3MDa

  • Elasticity mode G’ in rest 0,5 Hz / running 2,5 Hz: 242 Pa / 468 Pa
  • Viscosity mode G“ at rest/running: 180 Pa/220 Pa
  • 60 mg hyaluronic acid per syringe (20 mg / ml) 90 mg chondroitin sodium sulfate (30 mg / ml)

    3 ml pre-filled syringe

BIOPORT® CROSSLINK 2% /// PROPERTIES

Only one injection per treatment

Highly concentrated: 60mg hyaluronic acid per syringe with chondroitin for cartilage tissue

Delivered in pre-filled glass syringe Becton Dickinson

CHONDROITIN SULFATE

Protects the cartilage and decreases inflammatory activity in the region affected by osteoarthritis (OA). Contributes to physical cross-linking of the hyaluronate chains being binded thereto in a 1:1 ration, increasing in this way the properties of sodium hyaluronate.

INDICATION

  • As a viscoelastic supplement or as a replacement for the synovial fluid in the knee joint
  • For the symptomatic treatment of mild to severe knee osteoarthritis

EFFECTS

  • Pain relief
  • Improvement of joint mobility
  • Protection of the cartilage

APPLICATION

A single injection of the product restores the protection of the joint through good lubrication and shock absorption and leads to a significant improvement in symptoms.

PAIN RELIEF THAT TARGETS THE PAIN DIRECTLY

BIOPORT intra-articular injections are non-surgical alternatives in early intervention orthopedic care, aiming at providing safe, long-lasting pain relief.

BIOPORT® TRICOMBO

It is a biological matrix in the form of a sterile, viscoelastic solution containing Sodium hyaluronate and Chondroitin sodium surfate – two physically cross linked agents, highly purified polymers and N-acetylglucosamine(NAG),
a natural amino acid.

  • Composition: Sodium hyaluronate, Chondroitin sodium sulfate, N-acetylglucosamine

  • Concentration: 36 mg/67,5 mg/2,5ml 1,6%/3%/3%

  • Administration total: 1 syringe at 6 months

  • Average molecular weight: 3MDa

  • Elasticity mode G’ in rest 0,5 Hz / running 2,5 Hz: 250 Pa / 490 Pa

  • Viscosity mode G“ at rest/running: 190 Pa/275 Pa

BIOPORT® TRICOMBO /// PROPERTIES

Only one injection per treatment

Highly concentrated: 36mg hyaluronic acid per syringe with chondroitin sodium sulfate, N-acetylglucosamine

Delivered in pre-filled glass syringe Becton Dickinson

N-ACETYLGLUCOSAMINE

Reduces cartilage degeneration and activates its regeneration processes. Glucosamine is an important precursor of glycoprotein and GAG synthesis
As for the cartilage, it is essential for the formation of hyaluronic acid, chondroitin sulfate, and keratin sulfate, which are – apart from collagen fibers – the most important components of the extracellular matrix of articular cartilage and synovial fluid.

INDICATION

  • As a viscoelastic supplement or as a replacement for the synovial fluid in the knee joint
  • For the symptomatic treatment of mild to severe knee osteoarthritis

EFFECTS

  • Pain relief
  • Lubrication and mechanical support
  • Protection and regeneration of the cartilage

APPLICATION

A single injection of the product restores the protection of the joint through good lubrication and shock absorption and leads to a significant improvement in symptoms.

TO BE USED BY A PHYSICIAN ONLY

The injection of BIOPORT must be administered by authorized personnel depending on the needs of an individual patient and in accordance with local legislation.

BIOPORT® PLUS 1,5%

BIOPORT® CROSSLINK 2%

BIOPORT® LINEAR 80

BIOPORT® TRICOMBO

A WORLDWIDE PRESENCE

We believe in the power of collaboration, as partnerships achieve more.

BIOPORT Finland (HQ)
Life Science Center
Keilaranta 10 E, 02150 Espoo
+358 (0) 45214 8840
info@bioport.fi

BIOPORT FRANCE
3 rue du Premier de Ligne, 59400 CAMBRAI
+33 (0) 3 27 74 26 58
+33 (0) 6 44 28 0540
info@bioport.fr

SPAIN
INNOVACIONES EN ORTOPEDIA RENAC S.L.
Calle Ramon Cabanillas 16 bajo, 15679 Cambre – A Coruña
+34 619 975 275
renac@renac.es

ITALY
SIFRA SRL
Via dello Stadio, 20
51100 Pistoia
+39 0573 1716561 int.1
info@sifra-srl.it

TURKEY
Minerva Resources
Cumhuriyet Caddesi No: 65
Harbiye / Istanbul
info@minervaresources.com
*also for distribution in MENA

BALTIC STATES
(Latvia, Lithuania, Estonia)
SIA NUEVO
Ogre, Skolas iela 18, Ogre, Ogres nov., LV5001, Latvija
+37 126 699 005
info@nuevo.lv

UNITED ARAB EMIRATES
OREX MEDICAL TRADING LLC
Office no 2 Al Basha Bldg-6 Al Warsan 4
P.O. Box 239249 Dubai
Mohamad Elhadi {Marketing Manager}
+971-4-2240567
info@orexmedical.com

SOUTH AFRICA
Prime Surgical (Pty) Ltd
Unit A & B, 1 Avalon Road, Westlake View Ext 14,
Modderfontein,
Edenvale, South Africa
+27 11 531 5000
cx@sabiomedical.co.za

ARGENTINA
GRUPO ALEMANA
Avenida Vélez Sarsfield 55, Av. Vélez Sarsfield 55, C1282 Cdad.
Autónoma de Buenos Aires
www.grupoalemana.com
+54 114 409 5791
consultas@grupoalemana.com

BECOME OUR PARTNER

We are looking to create a distribution partnerships worldwide and will be delighted to help you with any inquiry that you may have.

    OSTEOARTHRITIS IS A LEADING CAUSE OF DISABILITY WORLDWIDE, LARGELY DUE TO ITS PRIMARY SYMPTOMS

    BIOPORT injections are used to keep joints moving and reduce pain, especially when other treatments have not been effective or are unsuitable.